Postgraduate in Mass Spectrometry

Preferred start date / 1st of July 2024 onwards

Duration: Initial contract up to two years

Your responsibilities:

• Provide support to the development of therapeutic protein characterization methods by liquid chromatography coupled to mass spectrometry (LC-MS) based workflows  
• Implementation of (semi-) quantitative methods for the monitoring and reporting of targeted product quality attributes as well as new peaks of therapeutic proteins using state-of-the-art LC-MS equipment and software, by e.g. multi-attribute method (MAM) or targeted LC-MS assay
• Plan and perform automated protein enzymatic digestion on a robotic system
• Perform project-specific method qualification and assessment of method robustness, where applicable
• Documentation of experiments and results in electronic systems

What you’ll bring to the role:

• Education: MSc in Biotechnology, Biochemistry, Analytical Chemistry or related field. Relevant work experience would be an asset.
• Languages: Strong communication skills in English; proficiency in German or French would be an asset
• Experience/Professional requirements:
  • Strong hands-on experience in liquid chromatography (HPLC and UHPLC e.g. Vanquish™)
  • Hands-on experience in protein sample preparation and analysis (e.g. peptide mapping by LC-MS) preferably using automated sample preparation on a robotic system (e.g. Hamilton STARlet)
  • Strong theoretical knowledge of protein biochemistry and protein posttranslational modifications
  • Theoretical knowledge and previous experience working with mass spectrometers (e.g. Orbitrap and Q-ToF analyzers)
  • Experience desired with selected reaction monitoring (SRM), parallel reaction monitoring (PRM), selected ion monitoring (SIM), or new peak detection (NPD)
  • Experience with Chromeleon and/or Genedata Expressionist would be an asset

Please submit a cover letter that includes your motivation for the position and from when you will be available. Thank you.

Commitment to Diversity and Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Accessibility and accommodation:

Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com, and let us know the nature of your request and your contact information. Please include the job requisition number in your message.